vGabriel Loeb, MD, PhD is a physician-scientist investigating the mechanisms underlying kidney disease. His research focuses on two major areas: 1) using human common genetic variation to identify cellular and molecular drivers of chronic kidney disease and 2) identifying the molecular mediators of Autosomal Dominant Polycystic Kidney Disease.

Findings from both projects demonstrate the central role of tubule epithelial cells in kidney disease pathogenesis. Gabriel’s research program integrates human genetics, novel kidney disease models, and single cell genomics to reveal essential regulators of tubule epithelial cell health and enable new therapies for people suffering from kidney disease.